This article examines the possibilities that the EPPO has under Regulation 2017/1939 to undertake cross-border measures relating to seizure and freezing. It concludes that, in the absence of a specific mechanism in the Regulation, some of the issues that may arise in practice could be solved by resorting to existing EU cooperation instruments on seizure and confiscation. However, questions, in particular as to the legal relationship or hierarchy between the Regulation and these other EU instruments will need to be addressed, ideally in the not too distant future and in the context of a fresh look at Art. 31 of the Regulation.